This page is provided as a supplementary material for Jeong et al (2022a and 2022b; AAPS J). Since calculations are carried out on the same mathematical basis between this page and the articles, please refer to the publications for detailed descriptions of the PBPK models used in this page. Please note that numerically slight difference may be present in model simulations due to the different operation environments (i.e., Python for the paper and JavaScript for this page).
Eigenvalues and eigenvectors for the PBPK system matrices are calculated by Linalg methods of SciPy/NumPy library for the articles and this page. Complex numbers are handled by Math.js for this page, and NumPy library for the articles. jQuery is used for the control of DOM entities. Plasma concentration-time profile in this calculation result is generated by Plotly.